Abstract: 【Background】Changes in soil enzyme activity can sensitively indicate soil biochemical processes and their responses to environmental disturbances, and is an effective biological indicator for evaluating the effectiveness of slope ecological restoration. Alternating drying and wetting processes in natural environments significantly affect soil enzyme activity and the nutrient cycling driven by it, but relevant research remains relatively insufficient, especially for special habitats such as artificially restored slopes. 【Methods】To explore the soil enzyme activities and their chemical stoichiometric characteristics during the decomposition process of litter on ecological restoration slopes under dry-wet conditions, and to enhance the stability and sustainability of artificial slope ecosystems, this study collected soil samples from typical vegetation concrete restoration slopes in Yichang City, Hubei Province. Using indoor simulation cultivation experiments, four field water holding capacity gradient treatments were set up: constant 40% (W₁), constant 70% (W₂), moderate dry-wet variation (W₃, 60% to 20%), and severe dry-wet variation (W₄, 100% to 35%). Five dry-wet variation cycles and no litter control were also set up. The contents of total soil organic carbon (SOC), ammonium nitrogen (NH₄⁺-N), and available phosphorus (AP) were determined, and the enzyme activities, enzyme stoichiometric ratios, and vector characteristics of β-1,4-glucosidase (BG), N-acetyl-β-amino-glucosidase (NAG), leucine aminopeptidase (LAP), neutral phosphatase (NP), cellulase (CBH), and polyphenol oxidase (PPO) were analyzed. 【Results】The results showed that the contents of SOC and NH₄⁺-N in the soil decreased with the dry-wet variation cycles. SOC decreased by 77.1% at the W₄ water gradient and by 17.8% at W₁. The decrease in the dry-wet variation treatments was significantly smaller than that in the constant water treatment (P＜0.05). 【Conclusion】In this study, the soil enzyme carbon-nitrogen-phosphorus ratios mostly deviated from 1:1:1. The maximum soil enzyme carbon-nitrogen ratio was 1.23, which was less than the global average of 1.41. The minimum enzyme nitrogen-phosphorus ratio was 0.59, which was higher than the global average of 0.44. This indicates that the selected Yichang vegetation concrete restoration slope overall has a relative deficiency of soil nitrogen elements, and the severe dry-wet variation exacerbated the soil nitrogen limitation. At the W₄ water gradient, the vector angle decreased by 9.8% with litter, and by 7.4% without litter. The decrease was slightly slower with the addition of litter, indicating that the addition of litter can alleviate the nutrient limitation caused by dry-wet variations.