Abstract: Guizhou Province is a region with Karst landform development.In recent years,with an increasing number of developments and construction and other human activities,the Karst region has been expanded seriously,which leads to a regional Karst collapse.In order to discuss the problem of Karst collapse in Guizhou,based on lots of case analysis,this paper studies the genesis of Karst collapse in Guizhou and the harm caused by Karst collapse.There are three environmental treatment measures summed up.This paper also discusses the method of exhaust pipe to treat the new karst collapse.All above mentioned is significant to study the Karst collapse in Guizhou Province.